Selected published papers Cover Articles Neuron. 2021 Neuron. 2020 Molecular Psychiatry. 2021 Journal of Neuroscience. 2022 Journal of Neuroscience. 2020 Journal of Neuroscience. 2018 Journal of Neuroscience. 2017 Journal of Neuroscience. 2016 Journal of Neuroscience. 2014 Genes＆ Development. 2012 Research Articles (2008- ) Cao R, Chen P, Wang H, Jing H, Zhang H, Xing G, Luo B, Pan J, Yu Z, Xiong WC, Mei L. Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals. Nat Commun. 2023 Feb 10;14(1):744. Wang H, Chen W, Dong Z, et al. A novel spinal neuron connection for heat sensation. Neuron. 2022;110(14):2315-2333.e6. Gao N, Liu Z, Wang H, Shen C, Dong Z, Cui W, Xiong WC, Mei L. Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons. J Neurosci. 2023 Sep 6;43(36):6249-6267. Tan Z, Liu Z, Liu Y, Liu F, Robinson H, Lin TW, Xiong WC, Mei L. An ErbB4-Positive Neuronal Network in the Olfactory Bulb for Olfaction. J Neurosci. 2022 Aug 24;42(34):6518-6535. Arzola E, Xiong WC, Mei L. Stress Reduces Extracellular ATP in the Prefrontal Cortex and Activates the Prefrontal Cortex-Lateral Habenula Pathway for Depressive-like Behavior. Biol Psychiatry. 2022 Aug 1;92(3):172-174. H.L. Robinson, Z. Tan, I. Santiago-Marrero, E.P. Arzola, Timothy Dong, W.-C. Xiong, L. Mei. Neuregulin 1 and ErbB4 kinase actively regulate sharp wave ripples in the hippocampus. J. Neurosci. (Cover). 2022 Z. Yu, M. Zhang, H. Jing, P. Chen, R. Cao, P. Pan, B. Luo, Y. Yu, B.M. Quarles, W.C. Xiong, M.H. Rivner, and L. Mei. Characterization of LRP4/agrin Antibodies from a Patient with Myasthenia Gravis. Neurology 2021 [Preview by Lisak, Neurology Sep 07, 2021; 97 (10)] Cui, N. Gao, Z. Dong, C. Shen, H. Zhang, B. Luo, P. Chen, D. Comoletti, H. Jing,H. Wang, H. Robinson, W.C. Xiong, and L. Mei. In-trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.Current Biology , 2021 G. Xing, H. Jing, Z. Yu, P. Chen, H. Wang, W.C Xiong, and L. Mei. Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation. Neuron , 2021 (Preview by Bai and Zhang, Neuron , 109:1907-1909, 2021) (Cover) Wang, W. Cui, W. Chen, F. Liu, Z. Dong, G. Xing, B. Luo, N. Gao, W.-J. Zou, K. Zhao, H. Zhang, X. Ren, Z. Yu, H.L. Robinson, Z. Liu, W.C. Xiong, L. Mei. The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons. Molecular Psychiatry , 2021 (Cover) W.B. Chen*, B. Luo*, N.N. Gao*, H.W. Li, H.S. Wang, L. Li, W.P. Cui, L. Zhang, D. Sun, F. Liu, Z.Q. Dong, H.S. Zhang, H. B. Su, W.C. Xiong, and L. Mei. Neddylation of 1 is critical for the excitability of interneurons and seizure prevention. J. Clin. Invest . 2021 L. Zhang, H. Jing, H. Li, W. Chen, B. Luo, H-S. Zhang, Z-Q. Dong, L. Li, H-B. Su, W-C. Xiong and L. Mei. Neddylation is critical to cortical development by regulating Wnt/b-catenin signaling. Proc. Nat. Acad. Sci. USA. 2020 M.H. Rivner, B.M. Quarles, J.-X. Pan, Z. Yu, J.F. Howard Jr, A. Corse, M.M. Dimachkie, C. Jackson, T. Vu, G. Small, R.P. Lisak, J. Belsh, I. Lee, R.J. Nowak, V. Baute, S. Scelsa, J.A. Fernandes, Z. Simmons, A. Swenson, R. Barohn, R.B. Sanka, C. Gooch, E. Ubogu, J. Caress, M. Pasnoor, H. Xu, L. Mei. Clinical features of LRP4/agrin-antibody – positive myasthenia gravis: A multicenter study. Muscle & Nerve. 2020. N. Gao, K. Zhao, Y. Cao, X. Ren, H. Jing, Xing, W.-C. Xiong, and Lin Mei. A role of lamin A/C in preventing neuromuscular junction decline in mice. J. Neurosci. 2020 ( Cover) H. Zhang, W. Chen, Z. Tan, L. Zhang, Z. Dong, W. Cui, K. Zhao, H. Wang, H. Jing,R. Cao, C. Kim, J.G. Safar, W.-C. Xiong and L. Mei. A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance. J. Neurosci. , 2020. (featured by J. Cavieres-Lepe and N. Stuardo, J. Neurosci. 41:3749-3751). Z. Dong*, W. Chen*, C. Chen, H. Wang, W. Cui, Z. Tan, H. Robinson, N. Gao, B. Luo, L. Zhang, K. Zhao, W.C. Xiong and L. Mei. CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation. Neuron, 2020 (Cover; Preview by Chen & Maher, Neuron , 105:398-399, 2020). G. Xing, H. Jing, L. Zhang, Y. Cao, L. Li, K. Zhao, Z. Dong, W. Chen, H. Wang, R. Cao, W.C. Xiong, and L. Mei. A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 8:e49180,2019. H. Zhang, A. Sathyamurthy, F. Liu, L. Li, L. Zhang, Z. Dong, W. Cui, X. Sun, K. Zhao, H. Wang, H.-Y. H. Ho, W.C. Xiong, L. Mei. Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice. eLife. 2019. H. Wang,* F. Liu,* W. Chen,* X. Sun, W. Cui, Z. Dong, K. Zhao, H. Zhang, H. Li, G. Xing, E. Fei, B.-X. Pan, B.-M. Li, W.-C. Xiong, Lin Mei. Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice. Proc. Nat. Acad. Sci. USA. 2018 X.-D. Sun*,**, W.-B. Chen**, D. Sun**, J. Huang, Y.-Q. Li, J.-X. Pan, Y.-N. Wang, K. Zhao, Z.-Q. Dong, H.-S. Wang, L. Xiong, A. Xuan, S.-T. Zhao, A. Pillai, W.-C. Xiong* and L. Mei. Neogenin in amygdala for neuronal activity and information processing. Neurosci. 38:9600-9613, 2018 K. Zhao*, C. Shen,*,** L. Li, H. Wu, G. Xing, Z. Dong, W. Chen, H. Zhang, J. Pan, H. Wang, W. Cui, X.D. Sun, S. Li, X. Li, X. Huang, W.C. Xiong, and L. Mei**. Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing Lrp4. J. Neurosci. 2018. (Cover) C. Shen*,**, L. Li**, K. Zhao**, L. Bai, A. Wang, X. Shu, Y. Xiao, J. Zhang, K. Zhang, T. Hui, W. Chen, B. Zhang, W. Hsu, W.-C. Xiong, L. Mei*. Motoneuron Wnts regulate neuromuscular junction development. eLife. 2018 Z. Tan, H. Robinson, D. Yin, Y. Liu, F. Liu, H. Wang, T.W. Lin, G. Xing, W.C. Xiong,L. Mei. Dynamic ErbB4 activity in hippocampal-prefrontal synchrony and top- down attention in rodents. Neuron. 2018. M. Yan, Z. Liu, E. Fei, W. Chen, X. Lai, B. Luo, P. Chen, H. Jing, J. Pan, M. Rivner, W.C. Xiong, and L. Mei. Induction of anti-agrin antibodies causes myasthenia gravis in mice. Neuroscience, 2018 T.W. Lin, Z. Tan, A. Barik, D. Yin, E. Brudvik, H. Wang, W.C. Xiong, L. Mei. Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive Interneurons. J. Neurosci. 2018 Y.-N. Wang, D. Figueiredo, X.-D. Sun, Z.-Q. Dong, W.-B. Chen, W.-P. Cui, F. Liu, H.-S. Wang, H.-W. Li, H. Robinson, E.-K. Fei, B.-X. Pan, B-M Li, W-C Xiong and L. Mei. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of SNARE-complex. Proc. Nat. Acad. Sci. USA. 2018 K. Zhao, C. Shen, Y. Lu, Z. Huang, L. Li, C.D. Rand, J. Pan, X.D. Sun, Z. Tan, H. Wang, G. Xing, Y. Cao, W.C. Xiong, and L. Mei. Muscle Yap is a regulator of neuromuscular junction formation and regeneration. J. Neurosci. 2017 ( Cover) (Highlighted by Faculty 1000 ). H.F. Jiao*, X.D. Sun*, R. Bates*, L. Xiong, F. Liu, L. Li, H.S. Zhang, S.Q. Wang, M.T. Xiong, M. Patel, A.M. Stranahan, W.C. Xiong, B.M. Li#, L. Mei#. Tmem108 is required for glutamatergic transmission in dentate gyrus. Proc. Nat. Acad. Sci. USA. 2017 M.H. Rivner, S. Liu, B. Quarles, B. Fleenor, C. Shen, J. Pan, L. Mei. Agrin and low‐ density lipoprotein– related receptor protein 4 antibodies in amyotrophic lateral sclerosis patients. Muscle & Nerve. 2017 L. Li,* Y. Cao,* H. Wu, X. Ye, Z. Zhu, G. Xing, C. Shen, A. Barik, B. Zhang, X. Xie, W. Zhi, L. Gan, H. Su, W.C. Xiong, L. Mei. Enzymatic activity of the scaffold protein rapsyn for synapse formation. Neuron, 2016. A. Barik1,# L. Li#, A. Sathyamurthy, W.C. Xiong, and L. Mei. Schwann cells in neuromuscular junction formation and maintenance. J. Neurosci. 2016. (Cover) X.D. Sun,*,** L. Li*, F. Liu, Z.H. Huang, J.C. Bean, H.F. Jiao, A. Barik, S.M. Kim, H. Wu, C. Shen, Y. Tian, T.W. Lin, R. Bates, A. Sathyamurthy, Y.J. Chen, D.M. Yin, L. Xiong,P. Lin, J.X. Hu, B.M. Li, T.M. Gao, W.C. Xiong, Lin Mei**. Lrp4 in astrocytes modulates glutamatergic transmission. Nature Neuroscience, 2016 H. Wu*, A. Barik*, Y. Lu, C. Shen, A. Bowman, L. Li, A. Sathyamurthy, T. Lin, W.C. Xiong, and L. Mei. Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. eLife. 2015 A. Sathyamurthy, D.M. Yin, A. Barik, C.Y. Shen, J. Bean, J.X. She, W.C. Xiong and L. Mei. ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination. Development 142: 522-532, 2015. Y. Lu,* X.-D. Sun,* F.-Q. Hou, F. Liu, L.L. Bi, D.M. Yin, Y.J. Chen, J. Bean, H.F. Jiao,X. Liu, B.M. Li, W.C. Xiong, T.M. Gao** and L. Mei**. Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory. Neuron 84:835-846, 2014 Y. Tao*, C. Shen*, S. Luo*, W. Traoré*, S. Marchetto, M.-J. Santoni, L. Xu, B. Wu,R. Bates, X. Liu, W.C. Xiong, J.-P. Borg**, and L. Mei**. Role of Erbin in ErbB2-dependent breast tumor growth. Proc. Nat. Acad. Sci. USA 111:4429-4438, 2014. A. Barik*, Y. Lu*, A. Sathyamurthy, A. Bowman, C. Shen, L. Li, W.C. Xiong and L. Mei. LRP4 is critical for neuromuscular junction maintenance. J. Neurosci. (*, co-first) 34:13892-13905, 2014 (Cover). J.C. Bean, T.W. Lin, A. Sathyamurthy, D.M. Yin, W.C. Xiong, and L. Mei. Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain. J. Neurosci. 34:13549-1366, 2014. (Highlighted in This Week in the Journal, Journal of Neuroscience). A. Barik, B. Zhang, G.S. Sohal, W.C. Xiong, L. Mei. Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. Dev. Neurobiol. 74:828-838, 2014. B. Zhang*, C. Shen*; B. Bealmear, S. Ragheb, W.-C. Xiong, R.A. Lewis, R.P. Lisak and L. Mei. Autoantibodies to agrin in myasthenia gravis patients. PLos One 9(3):e91816, 2014 D.M. Yin, X.D. Sun, J.C. Bean, T.W. Lin, A. Sathyamurthy, W.C. Xiong, T.M. Gao, Y.J. Chen* and L. Mei*. Regulation of spine formation by ErbB4 in PV-positive interneurons.J. Neurosci. 33:19295-19303, 2013 C. Shen*, B. Zhang*, Y. Lu*, D. Figueiredo , H. Wu, B. Arnab, W.C. Xiong and L. Mei. Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis. J. Clin. Invest. 123:5190– 5202, 2013. D.M. Yin*, Y.J. Chen*, Y.S. Lu, J.C. Bean, A. Sathyamurthy, C.Y. Shen, X.H. Liu, T.W. Lin, C.A. Smith, W.C. Xiong, and L. Mei. Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron 78:644-657,2013. (Highlighted by Preview, Neuron 78:577, 2013) Y. Tao*, Y. Chen*, C. Shen*, Z. Luo, C.R. Bates, D. Lee, S. Marchetto, T.-M. Gao, J. -P. Borg, W.C. Xiong, Lin Mei. Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neuroscience 16:290- 299, 2013. C. Liang*, Y. Tao*,**, C. Shen, Z. Tan, W.C. Xiong, L. Mei**. Erbin is required for myelination in regenerated axons after injury. J. Neurosci. , 32:15169-15180, 2012 B. Zhang, C. Liang, R. Bates, Y. Yin, W.C. Xiong, L. Mei. Wnt proteins regulate AChR clustering in muscle cells. Mol. Brain ,5 :7 doi:10.1186/1756-6606-5-7, 2012. H.T. Wu, Y.S. Lu, C.Y. Shen, W.C. Xiong, L. Mei. Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron , 75:94-107, 2012. H.T. Wu*, Yisheng Lu*, A. Barik, A. Joseph, M.M. Taketo, W.C. Xiong, L. Mei. beta -Catenin gain of function in muscles impairs neuromuscular junction formation. Development, 139:2392-2404, 2012. B. Zhang, J.S. Tzartos, M. Belimezi, S. Ragheb, B. Bealmear, R.A. Lewis, W.C. Xiong, R.P. Lisak, S.J. Tzartos, Lin Mei. Autoantibodies to LRP4 in patients with double-seronegative myasthenia gravis. Archive Neurol. 69:445-451, 2012. (Highlighted by Editorial, same issue, Archive Neurol. , 2012) X.H. Liu, R. Bates, D.M. Yin, C.Y. Shen, F. Wang, S. Nan, S.A. Kirov, Y. Luo, J.-Z. Wang, W.C. Xiong, and L. Mei. Specific regulation of NRG1 isoform expression by neuronal activity. J. Neurosci. 31:8491-8501, 2011. A. Ting, Y. Chen, L. Wen, D.M. Yin, C. Shen, Y. Tao, X. Liu, W.C. Xiong, L. Mei. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J. Neurosci. 31:15-25, 2011. L. Wen1, Y.S. Lu1, X. Zhu1, X.M. Li, R.-S. Woo, Y.-J. Chen, D.-M. Yin, C. Lai, A.Vazdarjanova, W.C. Xiong, and L. Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Nat. Acad. Sci. USA 107:1211-1216, 2010. Y. Tao, P. Dai, Y. Liu, S. Marchetto, W.C. Xiong, J.-P. Borg, L. Mei. Erbin regulates NRG1 signaling and myelination. Proc. Nat. Acad. Sci. USA. 2009. (Highlighted at Faculty of 1000) G. C. Dobbins, S.-w. Luo, Z. Yang, W.C. Xiong, Lin Mei. alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering. Mol. Brain 1:18, 2008. B. Zhang, S. Luo, Q. Wang, T. Suzuki, W.C. Xiong, Lin Mei. LRP4 serves as a co- receptor of agrin. Neuron 60:285-297, 2008 (highlighted in Nature 455:1153, 2008; Nature Rev. Neurosci. 9:886, 2008; Neuron , 60:526, 2008). S. Luo, B. Zhang, X.-p. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C.A. Chiu,C. Xiong, L. Mei. HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008. (Highlighted at Faculty 1000) C.-H. Kim, H.Neiswender, E.J. Baik, W.C. Xiong, and Lin Mei. Beta-Catenin interacts with MyoD and regulates its transcription activity. Mol. Cell Biol. 28:2941-2951, 2008. M. Li*, X.-P. Dong*, S.W. Luo, B. Zhang, D.H. Lee, A.K.L. Ting, H. Neiswender, C.H. Kim, E. Carpenter-Hyland, T.M. Gao, W.C. Xiong, L. Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin.Nature Neurosci. 11:262-268, 2008 (Highlighted in Nature Neurosci. 2008 and in Science Signal. 1:ec81, 2008). D. Zhu, Z. Yang, Z. Luo, S. Luo, W.C. Xiong, Lin Mei. MuSK endocytosis in AChR clustering in response to agrin. J.Neurosci. 28:1688-1696, 2008. Q. Wang, B. Zhang, Y.E. Wang, W.C. Xiong, L. Mei. The Ig1/2 Domain of MuSK Binds to Muscle Surface and Is Involved in Acetylcholine Receptor Clustering. Neurosignals. 16:246-253, 2008. PMID:18253062
