Publications

Full List of Publications Can Be Found Here

Selected Recent Publications:

2021

W.B. Chen*, B. Luo*, N.N. Gao*, H.W. Li, H.S. Wang, L. Li, W.P. Cui, L. Zhang, D. Sun, F. Liu, Z.Q. Dong, H.S. Zhang, H. B. Su, W.C. Xiong, and L. Mei. Neddylation of Nav1.1 is critical for the excitability of interneurons and seizure preventionJ. Clin. Invest. (*, equal contribution) 131(8):e136956. doi.org/10.1172/JCI136956, 2021 (Commentary by S.C. Cannon, Epilepsy channelopathies go neddy: stabilizing NaV1.1 channels by neddylation. JCI 131(8):e148370). PMID: 33651714 / PMCID: PMC8262483.

H. Wang, W. Cui, W. Chen, F. Liu, Z. Dong, G. Xing, B. Luo, N. Gao, W.-J. Zou, K. Zhao, H. Zhang, X. Ren, Z. Yu, H.L. Robinson, Z. Liu, W.C. Xiong, L. Mei. The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons. Molecular Psychiatry 2021 May 14. doi: 10.1038/s41380-021-01137-7. Online ahead of print. PMID: 33990773.

G. Xing, H. Jing, Z. Yu, P. Chen, H. Wang, W.C Xiong, and L. Mei. Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation. Neuron 109:1963-1978, 2021 (Cover and Preview by Bai and Zhang, Neuron, 1907-1909, 2021). PMID: 34033754 / PMCID: PMC8217331.

W. Cui, N. Gao, Z. Dong, C. Shen, H. Zhang, B. Luo, P. Chen, D. Comoletti, H. Jing, H. Wang, H. Robinson, W.C. Xiong, and L. Mei. In-trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development. Current Biology 2021 Aug 9;31(15):3330-3342.e7. doi: 10.1016/j.cub.2021.05.045. PMID: 34143959.

Z. Yu, M. Zhang, H. Jing, P. Chen, R. Cao, P. Pan, B. Luo, Y. Yu, B.M. Quarles, W.C. Xiong, M.H. Rivner, and L. Mei. Characterization of LRP4/agrin Antibodies from a Patient with Myasthenia Gravis. Neurology 2021 Sep 7;97(10):e975-e987. (Preview by Lisak, Neurology Sep 07, 2021; 97 (10))  Doi: 10.1212/WNL.0000000000012463. PMID: 34233932.

2020

Z. Dong*, W. Chen*, C. Chen, H. Wang, W. Cui, Z. Tan, H. Robinson, N. Gao, B. Luo, L. Zhang, K. Zhao, W.C. Xiong and L. Mei. CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation. Neuron105: 475-490, 2020 (Cover; Preview by Chen & Maher, Neuron, 105:398-399, 2020). PMID:31780330 / PMCID:PMC7007399. Doi: 10.1016/j.neuron.2019.10.035.

H. Zhang, W. Chen, Z. Tan, L. Zhang, Z. Dong, W. Cui, K. Zhao, H. Wang, H. Jing, R. Cao, C. Kim, J.G. Safar, W.-C. Xiong and L. Mei. A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance. J. Neurosci., 2020 Jul 8;40(28):5347:5361. Doi: 10.1523/jneurosci.0250-20.2020. Epub 2020 May 26. PMID:32457076 / PMCID:PMC7343327 (JC by J. Cavieres-Lepe and N. Stuardo, J. Neurosci. 41:3749-3751).

N. Gao, K. Zhao, Y. Cao, X. Ren, H. Jing, G. Xing, W.-C. Xiong, and Lin Mei. A role of lamin A/C in preventing neuromuscular junction decline in mice. J. Neurosci.40:7203-7215, 2020 (Cover). PMID: 32817327 / PMCID: PMC7534915. Doi: 10.1523/JNEUROSCI.0443-20.2020.

M.H. Rivner, B.M. Quarles, J.-X. Pan, Z. Yu, J.F. Howard Jr, A. Corse, M.M. Dimachkie, C. Jackson, T. Vu, G. Small, R.P. Lisak, J. Belsh, I. Lee, R.J. Nowak, V. Baute, S. Scelsa, J.A. Fernandes, Z. Simmons, A. Swenson, R. Barohn, R.B. Sanka, C. Gooch, E. Ubogu, J. Caress, M. Pasnoor, H. Xu, L. Mei. Clinical features of LRP4/agrin-antibody – positive myasthenia gravis: A multicenter studyMuscle & Nerve 62:333–343, 2020. PMID: 32483837 / PMCID: PMC7496236. Doi: 10.1002/mus.26985.

L. Zhang, H. Jing, H. Li, W. Chen, B. Luo, H-S. Zhang, Z-Q. Dong, L. Li, H-B. Su, W-C. Xiong and L. Mei. Neddylation is critical to cortical development by regulating Wnt/b-catenin signaling. Proc. Nat. Acad. Sci. USA. 117:26448-26459, 2020. PMID: 33020269 / PMCID: PMC7584916 Doi: 10.1073/pnas.2005395117.

2019

H. Zhang, A. Sathyamurthy, F. Liu, L. Li, L. Zhang, Z. Dong, W. Cui, X. Sun, K. Zhao, H. Wang, H.-Y. H. Ho, W.C. Xiong, L. Mei. Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice. eLife 8:e45303 DOI: 10.7554/eLife.45303, 2019. PMID:31268420 / PMCID:PMC6650252.

G. Xing, H. Jing, L. Zhang, Y. Cao, L. Li, K. Zhao, Z. Dong, W. Chen, H. Wang, R. Cao, W.C. Xiong, and L. Mei. A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 8:e49180, 2019. PMID:31549961 / PMCID:PMC6779466 Doi: 10.7554/eLife.49180.

2018

Y.-N. Wang, D. Figueiredo, X.-D. Sun, Z.-Q. Dong, W.-B. Chen, W.-P. Cui, F. Liu, H.-S. Wang, H.-W. Li, H. Robinson, E.-K. Fei, B.-X. Pan, B-M Li, W-C Xiong and L. Mei. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of SNARE-complexProc. Nat. Acad. Sci. 115:2508-2513, 2018. PMID:29463705 / PMCID:PMC5877931 DOI: 10.1073/pnas.1716322115.

T.W. Lin, Z. Tan, A. Barik, D. Yin, E. Brudvik, H. Wang, W.C. Xiong, L. Mei. Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive InterneuronsJ. Neurosci. 38:2533-2550, 2018. PMID:29431653 / PMCID:PMC5858595 DOI: 10.1523/JNEUROSCI.0669-17.2018.

M. Yan, Z. Liu, E. Fei, W. Chen, X. Lai, B. Luo, P. Chen, H. Jing, J. Pan, M. Rivner, W.C. Xiong, and L. Mei. Induction of anti-agrin antibodies causes myasthenia gravis in mice. Neuroscience, 373:113-121, 2018. PMID:29339325 / PMCID:PMC5942223 Doi: 10.1016/j.neuroscience.2018.01.015.

Z. Tan*, H. Robinson*, D. Yin, Y. Liu, F. Liu, H. Wang, T.W. Lin, G. Xing, W.C. Xiong, L. Mei. Dynamic ErbB4 activity in hippocampal-prefrontal synchrony and top-down attention in rodents. Neuron 98:380-393, 2018. PMID:29628188 / PMCID:PMC5909841 Doi: 10.1016/j.neuron.2018.03.018 (*equal contributing).

C. Shen*,**, L. Li**, K. Zhao**, L. Bai, A. Wang, X. Shu, Y. Xiao, J. Zhang, K. Zhang, T. Hui, W. Chen, B. Zhang, W. Hsu, W.-C. Xiong, L. Mei*. Motoneuron Wnts regulate neuromuscular junction development. eLife. 7, 2018 pii: e34625. doi: 10.7554/eLife.34625 (*, co-corresponding; **, co-first). PMID:30113308.

K. Zhao*, C. Shen,*,** L. Li, H. Wu, G. Xing, Z. Dong, W. Chen, H. Zhang, J. Pan, H. Wang, W. Cui, X.D. Sun, S. Li, X. Li, X. Huang, W.C. Xiong, and L. Mei**. Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing Lrp4. J. Neurosci.38:8860-8873, 2018. (Cover) *, equal contributing; **, co-corresponding. PMID:30171091 / PMCID:PMC6181315 Doi: 10.1523/JNEUROSCI.0860-18.2018.

H. Wang,* F. Liu,* W. Chen,* X. Sun, W. Cui, Z. Dong, K. Zhao, H. Zhang, H. Li, G. Xing, E. Fei, B.-X. Pan, B.-M. Li, W.-C. Xiong, Lin Mei. Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice. PNAS115:13105-13110, 2018. PMID:30498032 / PMCID:PMC6304932 Doi: 10.1073/pnas.1811287115.

Selected Recent Reviews:

G. Xing, W.C. Xiong, L. Mei. Rapsyn as a signaling and scaffolding molecule in NMJ formation and maintenance. Neurosci. Lett. 731:1350132, 2020

M Yan, GL Xing, WC Xiong, L Mei. Agrin and LRP4 antibodies as new biomarkers of myasthenia gravis. Ann. New York Acad. Sci. 1413: 126-135, 2018.

L. Li, W.C. Xiong, L. Mei, Neuromuscular junction formation, aging, and disorders. Ann. Rev. Physiol. 2018

Mei and K.-A. Nave, A neuregulin and ErbB network in the nervous system. Neuron 83:27-49, 2014

Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010

Mei and W.C. Xiong, Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008.